Spero Therapeutics Inc (FRA:2HA)
€ 1.222 -0.032 (-2.55%) Market Cap: 65.12 Mil Enterprise Value: 12.44 Mil PE Ratio: 3.91 PB Ratio: 0.89 GF Score: 29/100

Q2 2024 Spero Therapeutics Inc Earnings Call Transcript

Aug 05, 2024 / 08:30PM GMT
Release Date Price: €1.18 (-6.52%)

Key Points

Positve
  • Spero Therapeutics Inc (SPRO) reported a significant increase in total revenue for Q2 2024, reaching $10.2 million compared to $2.7 million in Q2 2023.
  • The company has a strong cash position with $63.5 million in cash and cash equivalents, along with anticipated milestone payments from GSK totaling $24 million every six months.
  • Enrollment for the Phase 3 PIVOT-PO clinical trial for tebipenem HBr is on track, with completion expected in the second half of 2025.
  • SPR720 shows promise as a first-line oral agent for nontuberculous mycobacterial pulmonary disease (NTMPD), with comprehensive data expected in Q4 2024.
  • SPR206 received FDA clearance to advance into a Phase 2 clinical trial and was awarded fast-track designation, indicating strong regulatory support.
Negative
  • The departure of Chief Medical Officer Dr. Kamal Hamed could indicate potential instability or challenges within the executive team.
  • Research and development expenses increased significantly to $23.7 million in Q2 2024 from $9.5 million in Q2 2023, impacting overall financial performance.
  • The company reported a net loss of $17.9 million for Q2 2024, higher than the $11.9 million loss in Q2 2023.
  • There is uncertainty regarding the mix of treatment-naive and treatment-experienced patients in the SPR720 trial, which could impact the interpretation of results.
  • The success of SPR720 and tebipenem HBr is contingent on future data readouts and regulatory approvals, which carry inherent risks and uncertainties.
Operator

Good afternoon, and welcome to the Spero Therapeutics second-quarter 2024 financial results conference call. (Operator Instructions) Please be advised that this call is being recorded and a replay will be available.

You can find information on the replay and further information related to today's announcements on the Spero Therapeutics' website at www.sperotherapeutics.com.

At this time, I would like to turn the call over to Shai Biran, Senior Director, Investor Relations. Mr. Biran, please go ahead.

Shai Biran
Spero Therapeutics Inc - Investor Relations

Thank you, operator, and thank you, all, for participating in today's conference call. This afternoon, Spero Therapeutics released financial results and provided a business update for the second quarter of 2024. The press releases available on the investor page of the Spero Therapeutics' website.

Before we begin, I would like to remind you that some of the information presented on this conference call

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